Bovine-derived Xenograft With or Without L-PRF for Alveolar Ridge Preservation After Tooth Extraction: a Randomized Controlled Trial

Mohammed Bin Rashid University of Medicine and Health Sciences

Status: Not yet enrolling

Conditions: Tooth Extraction; Dental Implants; Bone Regeneration

Treatments: Procedure: Alveolar ridge preservation using sticky bone

Study type: Interventional

Funder types: Other

Identifiers

NCT06172114

MBRU-PRF

Details and patient eligibility

About

The study is prospective randomized clinical trial that aims to evaluate the adjunctive use of L-PRF in promoting the desired vascularization and bone fill in small and large defects following tooth extraction and report on the long-term implant and patient outcomes

Enrollment: 34 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18 or over.
• Require extraction of anterior or posterior single tooth due to caries, endodontic and prosthetic complications.
• The tooth that requires extraction is bordered by two teeth.
• Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline).
• Good compliance and commitment to attend follow-up review appointments.
• Willing to provide informed consent.

Exclusion criteria

• Localised / generalised periodontitis.
• Presence of acute periapical lesion.
• Bone metabolic disease and/or taking medications that affect bone metabolism.
• Long term use of non-steroidal anti-inflammatory medications.
• History of malignancy, radiotherapy or chemotherapy.
• Pregnant or lactating women.
• Severe bruxism or parafunctional habits.
• Large occlusal discrepancies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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34 participants in 2 patient groups

Control group (C)

Active Comparator group

Description:

Xenograft + resorbable collagen membrane

Treatment:

Procedure: Alveolar ridge preservation using sticky bone

Test group (T)

Experimental group

Description:

Xenograft combined with L-PRF + resorbable collagen membrane

Treatment:

Procedure: Alveolar ridge preservation using sticky bone