Bowel Preparation May Lead to a Higher Feasibility of Intestinal Infection

Yanqing Li

Status and phase: Unknown; Early Phase 1

Conditions: Healthy

Treatments: Dietary Supplement: inulin; Combination Product: probiotic combination product; Drug: 2L of polyethyleneglycol

Study type: Interventional

Funder types: Other

Identifiers

NCT05277090

2021-SDU-QILU-088

Details and patient eligibility

About

An adequate bowel preparation is essential for a high quality of colonscopy. Nowdays, polyethyleneglyco is considered the most safe drug for bowel preparation, and is widely used around the world. However, previous study illustrated that bowel preparation by polyethyleneglyco could lead to qualitative changes in the intestinal microbiota both in mice and human. This study is aimed to investigate wether the changes in the intestinal microbiota could lead to a higher rate of intestinal infection.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients who agree to participant in the study

Exclusion criteria

• patients who couldn't stand polyethyleneglycol or inulin patients couldn't provide Informed consent patients who are suffering from sever heart disease, pulmonary disease or renal dysfunction.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

polyethyleneglycol only

Experimental group

Description:

participants take 2L of polyethyleneglycol only

Treatment:

Drug: 2L of polyethyleneglycol

polyethyleneglycol puls Inulin

Experimental group

Description:

participants take 2L of polyethyleneglycol, subsequently take 15g inulin per day.

Treatment:

Dietary Supplement: inulin

Drug: 2L of polyethyleneglycol

polyethyleneglycol puls probiotic combination product

Experimental group

Description:

Participants take 2L of polyethyleneglycol, subsequently take 15g probiotics combination product (including Bifidobacterium lactis, Lactobacillus plantarum, inlulin, Vitamin C) per day. The probiotic combination product, named "Mei Ri Yi Jun" was produced by Wedge Pharmaceuticals.

Treatment:

Drug: 2L of polyethyleneglycol

Combination Product: probiotic combination product