BPF Genetics of ILD Study (BPF GILD)

University of Dundee

Status

Active, not recruiting

Conditions

Lung Diseases, Interstitial

Bird Fancier's Lung

Idiopathic Interstitial Pneumonias

Idiopathic Pulmonary Fibrosis

Alveolitis, Extrinsic Allergic

Lung; Disease, Interstitial, With Fibrosis

Treatments

Diagnostic Test: Genetic profiling

Study type

Observational

Funder types

Other

Identifiers

NCT03747627

MS001

Details and patient eligibility

About

The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group.

We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.

Full description

The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings.

Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements.

Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.

Enrollment

475 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria