BPOI (Berlin Pediatric Oxygenation Index) - A New Predictor for Imminent Failure of HFNC in Children Avoiding Delayed NIV or Intubation

Charité University Medicine Berlin

Status: Withdrawn

Conditions: Respiratory Failure (Pediatric Patients)

Study type: Observational

Funder types: Other

Identifiers

NCT04895332

BPOI

Details and patient eligibility

About

The investigators developed an index that integrates different flow-settings in High-flow nasal cannula (HFNC) therapy with non-invasively measured clinical parameters of oxygenation in pediatric patients. This observational study is designed to evaluate this index and to determine a cut-off value for imminent HFNC failure.

Full description

High-flow nasal cannula therapy is a broadly used instrument of respiratory support in pediatric and adult patients with respiratory failure.

For adult patients with pneumonia and respiratory failure, there is a validated index (ROX; ratio SpO2/FiO2) which helps to identify those at risks for the need of intubation.

This index however is not applicable in the pediatric population because the physiological values of respiratory rate vary greatly across different ages.

Thus, based on the particularities of pediatric patients the investigators developed an index that integrates different flow-settings in HFNC therapy with non-invasively measured clinical parameters of oxygenation. The BPOI is defined as the ratio of the product of the peripherally measured oxygen saturation and the patient's body weight divided by the product of HFNC flow and the fraction of inspired oxygen:

BPOI = (SpO2 * kg) / (Flow * FiO2)

Sex: All

Ages: 28 days to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with respiratory failure and indication für High-flow nasal cannula therapy
• Patients aged between 4 1/7 weeks and 18 years
• Patients who were treated between 01/01/2017 and 28/02/2021 in the Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine at Campus Virchow- Klinikum, Charité - Universitätsmedizin Berlin

Exclusion criteria

• Patients aged between 1 and 27 days (neonatal period)
• Patients with congenital cyanotic heart defects
• Patients after or in the course of haematopoetic stem cell transplantation
• Patients with ambulatory respiratory support