Brain Activity, Cognitive Function, and Walking Ability in Parkinson's Disease

National Yang Ming Chiao Tung University

Status: Enrolling

Conditions: Parkinson Disease; Healthy Older Adults

Treatments: Behavioral: Cognitive function, gait, and electroencephalogram

Study type: Observational

Funder types: Other

Identifiers

NCT06588920

NYCU113006AF1

Details and patient eligibility

About

The dual-task automated walking performance in people with Parkinson's disease (PD) is affected by their gait disturbances and impaired executive functions. Currently, the relationship between brain activity related to inhibitory control, executive functions, and dual-task walking performance in people with PD is not well understood. Therefore, this study aims to investigate the significance of different executive function domains on gait stability in healthy older adults and people with PD; whether brain activation related to inhibitory control is associated with gait stability in healthy older adults and people with PD.

Enrollment: 70 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnoses of idiopathic Parkinson disease
• Stable dopaminergic medicine ≥ 2 weeks
• Able to walk 10 meters without aid
• Mini-Mental Status Examination ≥ 24 points
• No uncorrected visual or auditory disorders
• Education at least junior high school
• No other disease may affect balance

Exclusion criteria

• Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
• History of brain surgery (e.g. deep brain stimulation)

Trial design

70 participants in 2 patient groups

Parkinson disease

Description:

People with Parkinson disease

Treatment:

Behavioral: Cognitive function, gait, and electroencephalogram

Healthy older adults

Description:

Healthy older adults

Treatment:

Behavioral: Cognitive function, gait, and electroencephalogram