Brain Activity in Adults With ADHD During Neuropsychological Tasks

Kantonsspital Aarau

Status: Completed

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)

Treatments: Device: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT02578342

1410.000.055

Details and patient eligibility

About

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.

Full description

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood.

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.

Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.

Enrollment: 45 patients

Sex: All

Ages: 20 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participant is between 20-55 years old
• Participant is not pregnant

Exclusion criteria

• Participant is not able to consent him/herself
• Suspected or proven pregnancy
• Nursing
• Neurological diseases that could interfere with a diagnosis of ADHD
• Psychiatric comorbidity under treatment
• Previous history of psychiatric medication
• Substance abuse
• Intelligence quotient<75
• Claustrophobia
• Electrical simulator nerve or bone
• Implanted medication infusion pump
• Cerebral aneurysm clips
• Unstable medical condition

Trial design

45 participants in 3 patient groups

Healthy volunteers

Description:

healthy volunteer between age of 20 to 55 will undergo MRI examination.

Treatment:

Device: MRI

ADHD subjects without medication

Description:

Medication-naive subjects with ADHD (20-55 years) will undergo MRI examination.

Treatment:

Device: MRI

ADHD subjects with medication

Description:

Subjects with ADHD (20-55 years), under medication will undergo MRI examination.

Treatment:

Device: MRI