Brain Activity in Epilepsy

Universitaire Ziekenhuizen KU Leuven

Status: Enrolling

Conditions: Epilepsy

Treatments: Device: macro/micro electrode recording

Study type: Interventional

Funder types: Other

Identifiers

NCT05307146

S53126

Details and patient eligibility

About

Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.

Full description

The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.

The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.

Scientific objectives of the current project:

• To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
• To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
• Identifying pivotal regions for BMI applications and developing online decoding algorithms.
• Comparing neural recordings to fMRI activity

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 yo
• Epilepsy patients undergoing intracranial electrode placement.
• Able to understand the procedure involved and to consent.

Exclusion criteria

• Age < 18 yo
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

micro/macro electrode

Experimental group

Treatment:

Device: macro/micro electrode recording