Brain and Genetic Predictors of Individual Differences in Pain and Analgesia (PAINGEN)

Trustees of Dartmouth College

Status: Completed

Conditions: Pain, Acute

Treatments: Behavioral: Control Cream; Behavioral: Placebo Cream

Study type: Observational

Funder types: Other

Identifiers

NCT03781570

Pain Genetics

Details and patient eligibility

About

The purpose of the study is to gain a better understanding of pain processing in the brain. Our understanding of how pain is processed in the brain is limited. We are testing for individual differences in pain perception and emotion.

Enrollment: 541 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participants must be registered in the Colorado Community Twin Sample (CTS).

Exclusion criteria

• Not being registered in the Colorado Community Twin Sample (CTS).
• Any MRI contraindications.

Trial design

541 participants in 1 patient group

Single group

Description:

All participants are administered Control and Placebo creams (two interventions), with thermal and mechanical painful stimuli delivered repeatedly after each intervention. The order of intervention testing is Control, Placebo, Placebo, Control in a fixed order. All interventions are completed within a single testing session.

Treatment:

Behavioral: Placebo Cream

Behavioral: Control Cream