Brain and Mindfulness (MEDITATION)

Civil Hospices of Lyon

Status: Completed

Conditions: Healthy

Treatments: Other: Magneto-encephalography (MEG); Other: Anatomical Magnetic Resonance Imaging (aMRI); Other: Meditation; Other: Electro-encephalography (EEG); Other: Functional Magnetic Resonance Imaging (fMRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT03117478

69HCL16_0678

Details and patient eligibility

About

The main aim of this project is to explore the neuro-anatomical and -physiological correlates of meditation on attention and emotion-regulation. By investigating this, our scientific goal is to more generally identify the mechanisms and biomarkers of health and mental well-being. Therefore, the investigators use non-invasive imaging like Magneto-EncephaloGraphy (MEG), ElectroEncephaloGraphy (EEG), functional and anatomic Magnetic Resonance Imaging (MRI; including Diffusion tensor - DTI). These brain measures will then be linked to behavioral measurements. Experimental methods (i.e., simple computer tasks) will be used to measure attention, conscious perception and regulation of pain and emotion.

Enrollment: 169 patients

Sex: All

Ages: 25 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age : 25-70
• Being affiliated to a social security system.
• Motivated to participate in this study.

Exclusion criteria

• Medication acting on the central nervous system
• Opioids, Antidepressive Agents.
• Actual or previous neurological or psychiatric illnesses
• Chronic pain or any other medical condition which is related to pain or an increased sensitivity to pain.
• Not having a personal or family history of epilepsy
• Alcohol or drugs consumption 2 days before or during the study.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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169 participants in 4 patient groups

1. Participants without meditation experience

Other group

Description:

Novices. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.

Treatment:

Other: Magneto-encephalography (MEG)

Other: Meditation

Other: Electro-encephalography (EEG)

Other: Anatomical Magnetic Resonance Imaging (aMRI)

Other: Functional Magnetic Resonance Imaging (fMRI)

2. Participant with a significant meditation experience

Other group

Description:

Experts : \> 5000 hours of practice during their life. Note that there is no meditation intervention in this study but that the two groups differ in their lifetime meditation experience.

Treatment:

Other: Magneto-encephalography (MEG)

Other: Meditation

Other: Electro-encephalography (EEG)

Other: Anatomical Magnetic Resonance Imaging (aMRI)

Other: Functional Magnetic Resonance Imaging (fMRI)

3. Participants without meditation experience

Other group

Description:

Novices. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).

Treatment:

Other: Magneto-encephalography (MEG)

Other: Electro-encephalography (EEG)

Other: Anatomical Magnetic Resonance Imaging (aMRI)

Other: Functional Magnetic Resonance Imaging (fMRI)

4. Participant with a significant meditation experience

Other group

Description:

Experts : \> 5000 hours of practice during their life. There is no meditation intervention during the study but the investigators investigate the effects of meditation by comparing 2 groups who differ in their life time meditation experience (i.e., novices vs. experts).

Treatment:

Other: Magneto-encephalography (MEG)

Other: Electro-encephalography (EEG)

Other: Anatomical Magnetic Resonance Imaging (aMRI)

Other: Functional Magnetic Resonance Imaging (fMRI)