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Brain Blood Flow: Age and Gender

University of Wisconsin (UW) logo

University of Wisconsin (UW)

Status

Completed

Conditions

Aging
Healthy

Treatments

Device: MRI
Device: TCD

Study type

Observational

Funder types

Other

Identifiers

NCT02840851
EDUC/KINESIOLOGY/KINESIO (Other Identifier)
A176000 (Other Identifier)
2016-0403

Details and patient eligibility

About

Baseline cerebral blood flow through the middle cerebral artery (MCA) and cerebral vasodilator response of the MCA to inhaled carbon dioxide (CO2) will be measured in young women, young men, older women, and older men using Magnetic Resonance (MR) imaging and transcranial Doppler ultrasound (TCD). Data collection techniques will be compared.

Full description

The investigators have recently shown that cerebral blood flow responses to chemical stimuli are reduced in healthy older adults. The investigators also have preliminary data suggesting that sex differences in cerebrovascular regulation exist. The overall goal of this application is to extend on the investigators previous studies by employing advanced neuroimaging techniques to enhance the investigators understanding of neurovascular coupling in healthy aging. This study will collect clinically significant data with implications for the future risk of cognitive decline and Alzheimer's disease.

The research aims are:

  1. To determine the effect of age and sex on baseline cerebral blood flow through the middle cerebral artery (MCA).
  2. To determine the effect of age and sex on cerebral vasodilator responses.
  3. To determine if the cerebrovascular responses measured by transcranial Doppler ultrasound (TCD) are associated with the cerebrovascular responses measured by Magnetic Resonance (MR) imaging.

Enrollment

46 patients

Sex

All

Ages

20 to 64 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Between 20-34 or 50-69 years
  • Body mass index <34 kg/m2

Exclusion criteria

  • Current smoker
  • History or evidence of: hepatic disease, renal disease, hematological disease, peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)
  • Older females only: subject is not post-menopausal

Trial design

46 participants in 4 patient groups

Healthy young women
Description:
Healthy young women between the age of 20-34 years.
Treatment:
Device: TCD
Device: MRI
Healthy young men
Description:
Healthy young men between the age of 20-34 years.
Treatment:
Device: TCD
Device: MRI
Healthy older women
Description:
Healthy older women between the age of 50-64 years.
Treatment:
Device: TCD
Device: MRI
Healthy older men
Description:
Healthy older men between the age of 50-64 years.
Treatment:
Device: TCD
Device: MRI

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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