Brain Changes in Severely Depressed Patients Before and After Treatment With Electroconvulsive Therapy (ECT-IM)

Toulouse University Hospital

Status: Completed

Conditions: Severe Depression

Treatments: Device: 3T MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT02715986

15 7733 02 (Other Grant/Funding Number)

RC31/15/7733

Details and patient eligibility

About

Electroconvulsive therapy (ECT) is a non-pharmacological treatment used in resistant depression whose effectiveness has been demonstrated. However, the brain mechanisms underlying this therapeutic effect remain unclear. Many animal studies show a neurotrophic action of ECT on the hippocampus: increased neurogenesis, synaptogenesis, proliferation of glial cells. In addition, functional imaging of "resting state" type have shown, among depressed patients after ECT, increased functional connectivity . These results were reinforced by the recent work of Perrin (2012). In view of this a priori contradictory, it seems appropriate to continue research neuroanatomical correlates subtending neurofunctional processes responsible at the same time improving the clinical depressive. The investigators suggest using an original technique never used in this type of population: Functional magnetic resonance imaging (fMRI) or multimodal structural-functional. This method will allow us to study the impact of ECT on brain structures involved in major depressive disorder: hippocampus.

Enrollment: 17 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnostic and Statistical Manual of Mental Disorders-V (DSM) diagnosis of major depressive disorder
• indication of ECT and signing the consent for conducting a ECT
• right-handed
• be of French mother tongue
• belong to a social security scheme
• sign an informed consent

Exclusion criteria

• against indication for MRI
• against indication to anesthesia
• processes brain expensive
• pregnant woman
• refuse to be informed of an abnormality detected during MRI
• Patients holders of stimulation electrodes
• presence history of neurological disease
• presence history of head injury
• Mini-Mental State Examination (MMSE) <15/30
• presence of neurodegenerative disease
• patients who have had ECT treatment in the last 6 months

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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17 participants in 1 patient group

Severly depressed patients

Experimental group

Description:

Recruitment of twenty depressive subjects will be conducted within the hospital service adult psychiatry.These patients are referred for indication of ECT sessions for severe resistant depression. Four MRI evaluations (3T MRI examination) are programmed in such patients to analyze structural changes in the hippocampus.

Treatment:

Device: 3T MRI