Brain Connectivity Measured With High-density Electroencephalography (NEUROCONN)

IRCCS San Camillo, Venezia, Italy

Status: Enrolling

Conditions: Stroke

Treatments: Device: Connectivity measures

Study type: Interventional

Funder types: Other

Identifiers

NCT06298097

2019.11

Details and patient eligibility

About

Emerging scientific results show that disrupted functional connectivity in stroke can explain behavioral impairments and predict their recovery over time. However, no technique is yet available for widespread use in clinics to examine how neural synchronization in brain networks is altered in stroke patients. This is crucial to determine favorable prognostic factors and to define individualized rehabilitation protocols. Importantly, the investigators have successfully used high-density electroencephalography (hdEEG) in healthy individuals to measure neural synchronization in brain networks. In this project, the investigators will develop methods and tools based on hdEEG for assessing functional connectivity in stroke patients. These methods and tools will be employed to examine how neural changes occurring after brain lesions explain behavioral impairments. The project will open the way for the use of hdEEG at the patient's bedside, as a neurodiagnostic tool for stroke as well as other brain disorders.

Enrollment: 170 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

In this study 125 stroke patients and 45 healthy participants will be recruited at the Institute for Research and Healthcare with a Scientific Character (IRCCS) San Camillo hospital.

Inclusion Criteria (patients):

• right or left hemisphere damage
• unilateral stroke
• compliance with magnetic resonance imaging (e.g., no claustrophobia)

Inclusion Criteria (healthy participants):

• compliance with magnetic resonance imaging (e.g., no claustrophobia)

Exclusion Criteria (both patients and healthy participants):

• no comorbidities with psychiatric disorders

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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170 participants in 2 patient groups

stroke patients

Other group

Description:

Resting-state networks obtained through electroencephalography will be analyzed in a group of stroke patients.

Treatment:

Device: Connectivity measures

healthy participants

Other group

Description:

Resting-state networks obtained through electroencephalography will be analyzed in a group of healthy participants.

Treatment:

Device: Connectivity measures