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Brain Death: Inflammatory Response, Apoptosis, and Endotoxin Tolerance

D

Delafontaine Hospital

Status

Completed

Conditions

Brain Death

Treatments

Procedure: Muscle biopsy

Study type

Observational

Funder types

Other

Identifiers

NCT00615225
CCPPRB/114-02
Agence de Biomédecine 2005

Details and patient eligibility

About

We hypothesized that brain death is associated with an early systemic inflammatory response, possibly combined with activation of apoptotic cell death, two events that may contribute to induce rapid organ dysfunction. In this study of brain-dead donors and controls, we assayed plasma cytokines and soluble factors, investigated plasma endotoxin levels as a triggering factor for inflammation, measured ex vivo cytokine production by blood leukocytes to determine whether immunosuppression occurred after brain death, and examined skeletal muscle biopsies to look for evidence of inflammation and increased apoptosis in peripheral tissue.

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • All brain dead patients whatever the cause (cardiac arrest, stroke, head trauma)

Exclusion criteria

  • Age < 18years

Trial design

0 participants in 3 patient groups

Brain dead patients
Description:
All patients meeting criteria for brain death
Treatment:
Procedure: Muscle biopsy
Healthy control
Description:
Any healthy volunteers accepting to give some blood
Volunteers having hip surgery
Description:
Patients undergoing hip surgery for degenerative non-inflammatory hip disease
Treatment:
Procedure: Muscle biopsy

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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