Brain Death: Inflammatory Response, Apoptosis, and Endotoxin Tolerance

Delafontaine Hospital

Status: Completed

Conditions: Brain Death

Treatments: Procedure: Muscle biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT00615225

CCPPRB/114-02

Agence de Biomédecine 2005

Details and patient eligibility

About

We hypothesized that brain death is associated with an early systemic inflammatory response, possibly combined with activation of apoptotic cell death, two events that may contribute to induce rapid organ dysfunction. In this study of brain-dead donors and controls, we assayed plasma cytokines and soluble factors, investigated plasma endotoxin levels as a triggering factor for inflammation, measured ex vivo cytokine production by blood leukocytes to determine whether immunosuppression occurred after brain death, and examined skeletal muscle biopsies to look for evidence of inflammation and increased apoptosis in peripheral tissue.

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All brain dead patients whatever the cause (cardiac arrest, stroke, head trauma)

Exclusion criteria

• Age < 18years

Trial design

0 participants in 3 patient groups

Brain dead patients

Description:

All patients meeting criteria for brain death

Treatment:

Procedure: Muscle biopsy

Healthy control

Description:

Any healthy volunteers accepting to give some blood

Volunteers having hip surgery

Description:

Patients undergoing hip surgery for degenerative non-inflammatory hip disease

Treatment:

Procedure: Muscle biopsy