Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients

Shandong University

Status: Unknown

Conditions: Irritable Bowel Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT00925223

2009SDU-QILU-G02

NSFC30570831

Details and patient eligibility

About

Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently. Visceral hypersensitivity is recognized as a clinical hallmark in IBS patients. So in this study, the investigators will focus on the role of BDNF in colonic hyperalgesia in IBS patients.

Enrollment: 30 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients diagnosed with irritable bowel syndrome.

Exclusion criteria

• Patients have similar clinical symptoms as IBS, yet there is morphologic changes in the intestine.

Trial design

30 participants in 2 patient groups

irritable bowel syndrome

Description:

patients with diarrhea-predominant IBS will be enrolled in this group.

control group

Description:

patients with colon cancer or colon polyp will be enrolled as control group.