Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

St. Olavs Hospital

Status: Completed

Conditions: Depressive Disorder, Major; Depressive Disorder

Treatments: Behavioral: High aerobic intensity training (HIT); Behavioral: Long slow distance training (LSD)

Study type: Interventional

Funder types: Other

Identifiers

NCT02741622

2015/2230

Details and patient eligibility

About

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.

The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Enrollment: 21 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Moderate or severe depression (ICD10: F32-F33)

Exclusion criteria

• Bipolar disorder.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

Exercise

Experimental group

Description:

Acute High aerobic intensity training (HIT) and long slow distance training (LSD)

Treatment:

Behavioral: Long slow distance training (LSD)

Behavioral: High aerobic intensity training (HIT)