Brain Effects of Sacral Neuromodulation

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Urinary Tract Disease

Treatments: Radiation: Baseline neuroimaging; Radiation: Neuroimaging during sacral neuromodulation

Study type: Interventional

Funder types: Other

Identifiers

NCT00610064

KEK80_05

1025

Details and patient eligibility

About

Sacral neuromodulation (SNM) has become an accepted treatment for patients with refractory lower urinary tract dysfunction such as urgency frequency syndrome, urgency incontinence, non-obstructive chronic urinary retention and chronic pelvic pain syndrome. Modulation of central afferent activity is considered critical to this therapeutic effect but the neural mechanisms are poorly understood.

We hypothesize that SNM has a significant effect on brain activity detectable by positron emission tomography (PET).

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with refractory lower urinary tract dysfunction scheduled for sacral neuromodulation

Exclusion criteria

• Pregnancy
• Age <18 years
• Claustrophobia

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

A

Other group

Description:

Baseline neuroimaging

Treatment:

Radiation: Baseline neuroimaging

B

Other group

Description:

Neuroimaging during sacral neuromodulation

Treatment:

Radiation: Neuroimaging during sacral neuromodulation