Brain Exercises for Synaptic Plasticity (BEST)

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University of Kentucky

Status

Completed

Conditions

Cognitive Change

Treatments

Behavioral: Origami
Behavioral: Reading
Behavioral: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT03058055
BEST

Details and patient eligibility

About

The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts over an 8 week period, including active reading vs. origami study arms and a placebo group without structured cognitive intervention.

Full description

This is a randomized, placebo controlled study investigating the practical implementation and conduct of two cognitive interventions in non-demented subjects. Subjects will be randomized 1:1:1 into three groups including: 1) a Book club that includes weekly one hour meetings and daily reading assignments, 2) Origami lessons (one hour/week) with daily take home Origami activities to complete, and 3) a placebo group with unstructured lifestyle activities (normal lifestyle activities without restraint).

Enrollment

45 patients

Sex

All

Ages

65+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Non demented community dwelling elders

Exclusion criteria

Unable to perform the reading or origami tasks for any reason

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

45 participants in 3 patient groups, including a placebo group

Placebo
Placebo Comparator group
Description:
Usual lifestyle activities
Treatment:
Behavioral: Placebo
Origami
Experimental group
Description:
Origami lessons (one hour/week) with daily take home Origami activities to complete
Treatment:
Behavioral: Origami
Reading
Experimental group
Description:
Daily reading (out loud into a voice recorder) for one hour
Treatment:
Behavioral: Reading

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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