Brain Function and Perfusion in Patients With Heart Failure (BRAIN-HF)

University Medical Center Groningen (UMCG)

Status

Unknown

Conditions

Cognitive Impairment

Perfusion

Heart Failure

Cerebral Hypoperfusion

Dilated Cardiomyopathy

Study type

Observational

Funder types

Other

Identifiers

NCT01756014

BRAIN-HF

Details and patient eligibility

About

The investigators will evaluate the determinants of cerebral impairment in patients with non-ischemic heart failure compared to controls, and its relation to cognitive function. They hypothesize that patients with heart failure have impaired brain perfusion and hemodynamic factors are associated with cognitive dysfunction.

Enrollment

45 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria Control Group:

Healthy subject, as assessed by clinician
Age matched with patient group

Exclusion Criteria Control Group:

Age < 18 years
Carotid artery or intracranial disease, as assessed by echo-doppler (significant stenosis > 50%)
Unable or unwilling to undergo MRI
The presence of ferromagnetic material in or on the body, for example tattoos with ferrous ink or pacemakers or cardiac defibrillators. Also the presence of pregnancy and claustrophobia.
History of cognitive impairment
Unable to understand procedures
Unable or unwilling to provide informed consent

Inclusion Criteria DCM-group:

Heart failure due to DCM
15 patients with NYHA class II
15 patients with NYHA class III/IV

Exclusion Criteria DCM-Group:

Age < 18 years
History of myocardial infarction
History of peripheral artery disease
History of cerebrovascular disease or
Carotid artery or intracranial disease, as assessed by echo-doppler (significant stenosis > 50%)
History of cognitive impairment
Unable to undergo MRI (eg pacemaker)
Unable to understand procedures
Unable or unwilling to provide informed consent