Brain Function in Adolescent Eating Disorders and Healthy Peers

University of California San Diego

Status: Active, not recruiting

Conditions: Eating Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT03347565

170664

Details and patient eligibility

About

This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Enrollment: 155 patients

Sex: Female

Ages: 14 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female
• Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder
• Medically stable
• Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).

Exclusion criteria

• Psychotic illness/other mental illness requiring hospitalization
• Current dependence on drugs or alcohol
• Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).
• On psychoactive medication
• Organic brain syndromes, delirium, psychotic disorders, or intellectual disability
• Neurological or medical disorders such as seizure disorder
• Any contraindication to undergoing an MRI
• Major depressive disorder
• Left handed

Trial design

155 participants in 2 patient groups

Adolescents with an Eating Disorder

Description:

Females between the ages of 14-17 currently diagnosed with an eating disorder (including ARFID, Anorexia Nervosa, Bulimia Nervosa, OSFED)

Healthy Controls

Description:

Females between the ages of 14-17 with no psychiatric conditions