Brain Health Oneida

University of Wisconsin (UW)

Status: Active, not recruiting

Conditions: Oneida Nation Members

Treatments: Diagnostic Test: Carotid ultrasound; Diagnostic Test: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT07080866

SMPH/NEURO SURG/NEURO SURG (Other Identifier)

A535700 (Other Identifier)

2025-1005

Protocol Version 9/22/2025 (Other Identifier)

Details and patient eligibility

About

The purpose of this observational study is to better understand the relationship between stroke risk factors and brain MRI measures in the Native American population.

Participants will undergo:

• Carotid ultrasound
• Magnetic resonance imaging (MRI)
• Cognitive testing

Full description

Researchers' central hypothesis is that Native Americans (NAs) suffer from chronic psychological stress (PS) and inter-generational trauma related to historical loss (HL) which are manifested as inflammatory proteomic changes, leading to atherosclerotic vessel wall injury, stroke and vascular cognitive impairment (VCI). The researchers present a study to determine if MRI brain health metrics such as structural and functional connections, cerebral blood flow measures, brain morphometry are correlated with cardiovascular risk factors, atherosclerotic disease burden, blood inflammatory proteins, and scores on the Oneida cultural nutritional programs.

Enrollment: 19 patients

Sex: All

Ages: 55 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 55-90
• Receiving healthcare though the Oneida Comprehensive Health Division

Exclusion criteria

• Not Native American
• Contraindications to MRI scans

Trial design

19 participants in 1 patient group

Oneida Nation

Description:

Participants will be Native American and undergo MRI an ultrasound

Treatment:

Diagnostic Test: MRI

Diagnostic Test: Carotid ultrasound