Brain-imaging and Adolescent Neuroscience Consortium (BANC)

Boston Children's Hospital

Status: Withdrawn

Conditions: Alcohol Abuse

Study type: Observational

Funder types: Other

Identifiers

NCT01511679

BANC RFA-AA-12-006

Details and patient eligibility

About

This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.

Full description

The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.

Sex: All

Ages: 12 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• able to read and understand English
• available for follow-up
• parental consent/adolescent assent for those 12-17 years
• consent for those 18-21 years

Exclusion criteria

• Weight > 300 lbs
• braces or unremovable embedded metal
• claustrophobia or inability to lie still in MRI machine
• current or past 12-mos pregnancy (females)
• requires urgent medical/mental health care

Trial design

0 participants in 3 patient groups

Alcohol-naive adolescents

Description:

A general population longitudinal cohort of alcohol-naïve (or h/o minimal recent-onset drinking) adolescents in three specific age-groups: early (12-14 y/o), middle (15-17 y/o), and late (18-21 y/o).

Treatment sample

Description:

A sample of adolescents who have a \>1 year history of heavy drinking but have agreed to stop drinking as part of their treatment plan

High risk sample

Description:

High-risk adolescents who have a family history of alcohol-use disorder and other risk factors (symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), Conduct Disorder, or Mood Disorder)