Brain Imaging of Psychotherapy for Depression

University of North Carolina (UNC)

Status: Completed

Conditions: Major Depressive Disorder

Treatments: Behavioral: Brief Behavioral Activation Treatment for Depression

Study type: Interventional

Funder types: Other

Identifiers

NCT00609453

05-2605

NIMH R03 MH078145

Details and patient eligibility

About

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.

Enrollment: 27 patients

Sex: All

Ages: 21 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder
• For group 1: Hamilton Depression Rating Scale score of 15 or greater

Exclusion criteria

• A history of serious head injury or neurological disease or psychosis
• Current use of psychoactive medications
• Factors that could affect MRI safety including current or planned pregnancy
• For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview

Trial design

27 participants in 1 patient group

1

Experimental group

Description:

Individuals with major depressive disorder receiving therapy

Treatment:

Behavioral: Brief Behavioral Activation Treatment for Depression