Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)

US Department of Veterans Affairs (VA)

Status and phase: Completed; Phase 4

Conditions: Post-traumatic Stress Disorder

Treatments: Drug: Paroxetine

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00700999

MHBA-002-08S

Details and patient eligibility

About

The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can predict who will get better with treatment.

Enrollment: 65 patients

Sex: All

Ages: 21 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Veterans with clinical diagnosis of post-traumatic stress disorder from combat related to deployment to Afghanistan/Iraq (Operation Enduring Freedom/Operation Iraqi Freedom)

Exclusion criteria

• Intolerance or sensitivity to paroxetine
• Major medical or neurologic illness
• Current psychotropic medication or active psychotherapy treatment
• Other major psychiatric illness

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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65 participants in 2 patient groups

Arm 1

Other group

Description:

Intervention-Paroxetine

Treatment:

Drug: Paroxetine

Arm 2

No Intervention group

Description:

No Intervention