Brain Mechanisms of Reducing Polysubstance Use

Arizona State University (ASU)

Status: Enrolling

Conditions: Multiple Drug Use

Treatments: Behavioral: NF; Behavioral: IBMT

Study type: Interventional

Funder types: Other

Identifiers

NCT06324786

2024 IBMT NF

Details and patient eligibility

About

The proposed study will test whether neurofeedback (NF) could optimize integrative body-mind training (IBMT) practice.

Full description

The proposed study will test whether real-time NF could optimize IBMT practice and improve effects in reducing polysubstance use through targeting self-control networks in the brain.

Enrollment: 35 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• At least 18 years old
• Free of any psychiatric diagnoses or medication (besides a substance use disorder (SUD) to alcohol, tobacco, or cannabis)
• In the past month, at least 4 episodes of heavy episodic drinking; at least 3 occasions of cannabis use; and daily cigarette use for at least the past month
• Normal or corrected-to-normal vision
• Written informed consent
• No previous meditation or NF experiences

Exclusion criteria

• Any psychiatric diagnoses other than an SUD
• Medical disorder(s) that may affect the central nervous system; medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females)
• Excluding cannabis, evidence of recent (past month) illicit drug use

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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35 participants in 4 patient groups

IBMT

Experimental group

Description:

An evidence-based preventive intervention - integrative body-mind training (IBMT) has shown positive effects in reducing stress and improving self-control and brain plasticity. It has bodifulness and mindfulness components.

Treatment:

Behavioral: IBMT

NF

Experimental group

Description:

An evidence-based intervention - NF can not only provide real-time feedback for practice but also target the self-control networks, suggesting the possibility of augmenting IBMT effects via NF.

Treatment:

Behavioral: NF

IBMT + NF

Experimental group

Description:

The combined IBMT and NF also show positive effects in reducing substance use.

Treatment:

Behavioral: IBMT

Behavioral: NF

Sham NF

Sham Comparator group

Description:

Sham NF has the same settings as the active NF but does not have correct parameters of stimulation.

Treatment:

Behavioral: NF