Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects

Universitaire Ziekenhuizen KU Leuven

Status and phase: Completed; Phase 4

Conditions: Healthy Volunteers

Treatments: Drug: Placebo; Drug: Erythromycin

Study type: Interventional

Funder types: Other

Identifiers

NCT02212821

Erythromycin_v6

Details and patient eligibility

About

The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.

Enrollment: 14 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female only.
• Age > 18 and < 60.
• Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past three months).
• Not known to have any chronic medical illness or illnesses affecting the gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder.
• If female not known to be pregnant.
• Not known to have any past upper gastrointestinal surgery.

Exclusion criteria

• Alcohol consumption > 7 drinks / week
• Major depression and chronic health conditions except controlled hypertension

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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14 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

intravenous infusion

Treatment:

Drug: Placebo

Erythromycin

Experimental group

Description:

intravenous infusion

Treatment:

Drug: Erythromycin