Brain Metabolism in Polycystic Ovary Syndrome

Université de Sherbrooke

Status: Completed

Conditions: Insulin Resistance

Study type: Observational

Funder types: Other

Identifiers

NCT02409914

10-153

Details and patient eligibility

About

The purpose of this study is to investigate whether higher insulin resistance in young women with Polycystic ovary syndrome (PCOS) is associated with reduced cerebral metabolic rate of glucose (CMRglu). Brain volumes using magnetic resonance imaging (MRI) and quantitative cerebral glucose uptake using dynamic positron emission tomography (PET) were obtained.

Full description

MRI and FDG PET scan for each participant were obtained within an average time frame of 3 weeks. Isulin resistance were assessed with the updated homeostasis model assessment (HOMA2-IR).

Enrollment: 7 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of PCOS
• Age ≤ 35 y
• BMI ≤ 35

Exclusion criteria

• Taking medications for diabetes or insulin-sensitizing drugs
• Drug addictions
• Psychiatric illness
• Smoking
• Overt evidence of heart, liver or renal disease

Trial design

7 participants in 1 patient group

POLYCYSTIC OVARY SYNDROME (PCOS)

Description:

FDG PET scan,T1-weight MRI and blood were obtained for each participant