Brain Network Characteristics in Patients With Disorders of Consciousness

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Disorders of Consciousness

Treatments: Other: PET-fMRI-EEG

Study type: Observational

Funder types: Other

Identifiers

NCT05558670

20222068

Details and patient eligibility

About

Simultaneous measurement of the three modalities, functional magnetic resonance imaging (fMRI), positron emission tomography (PET) and electroencephalography (EEG) was proven to be feasible and advantageous in evaluating brain structural and functional (via fMRI), metabolic (via PET) and electrophysiological (via EEG) signatures simultaneously under the same conditions. Investigators use trimodal PET-fMRI-EEG imaging to explore the characteristics of brain network damage in patients with disorders of consciousness(DOC), assess the trajectory of consciousness recovery in a prospective observational cohort study.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Coma, VS/UWS, MCS and EMCS according to diagnostic criteria
2. Age ≥18 years
3. Written informed consent obtained

Exclusion criteria

1. Patients with contraindications to PET, MRI, EEG examinations or inability to complete PET-fMRI-EEG examinations (presence of ferromagnetic metal implants or hyperthermia)
2. Hyperglycemia that is difficult to correct
3. Patients with long-term use of corticosteroids
4. Patients with coexisting severe systemic disease and limited life expectancy

Trial design

40 participants in 4 patient groups

coma

Treatment:

Other: PET-fMRI-EEG

VS/UWS

Treatment:

Other: PET-fMRI-EEG

MCS

Treatment:

Other: PET-fMRI-EEG

EMCS

Treatment:

Other: PET-fMRI-EEG