Brain Oscillatory Signatures of Auditory Stimuli Across Different Vigilance and Sedation States

Insel Gruppe AG, University Hospital Bern

Status: Enrolling

Conditions: Sleep; Anesthesia

Treatments: Other: Acoustic stimuli

Study type: Interventional

Funder types: Other

Identifiers

NCT05799417

2022-00970 (Other Identifier)

Details and patient eligibility

About

The investigators want to explore how presenting acoustic stimuli influences brain oscillatory signatures and heart rhythm- dynamics across different vigilance and sedation states.

The investigators will administer acoustic stimuli during sedation and anaesthesia while brain activity and heart activity are being recorded by electroencephalogram and electrocardiogram.

On the day following anaesthesia an optional nap/sleep period's EEG and ECG will be recorded. During this short sleep, patients will again be exposed to acoustic stimuli. The recorded EEG and ECG will be compared intra-and inter-individually to recordings from sedation and anaesthesia.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 84 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Informed Consent as documented by signature
• Good general health status
• Planned ophthalmic/plastic surgery at Inselspital Berne

Exclusion criteria

• Contraindications on ethical grounds
• Neurological/neurodegenerative disorder
• Hearing problems (only if patients are not able to perceive the acoustic stimuli)
• Pacemaker
• Deep brain stimulator
• Pregnancy
• Known or suspected drug or alcohol abuse
• Critical surgery procedure

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

Acoustic stimuli

Experimental group

Description:

Acoustic stimuli and comparison to within-subject baseline

Treatment:

Other: Acoustic stimuli