Brain, Psychological and Epigenetic Determinants for Optimizing the Treatment of Chronic Low Back Pain

Université de Sherbrooke

Status

Enrolling

Conditions

Chronic Low-back Pain

Treatments

Other: No intervention

Study type

Observational

Funder types

Other

Identifiers

NCT05963451

2022-4293

Details and patient eligibility

About

The goal of this observational study is to better understand the role of the brain in chronic low back pain patients.

Full description

Chronic pain affects millions of people worldwide, and the main cardinal sign of any arthritis condition is pain. Several arthritis conditions can cause chronic low back pain (CLBP).The mechanisms that contribute to CLBP are not yet fully understood, but considering the role of the brain in the context of chronic pain, it is only logical to investigate structural and functional brain properties in CLBP, in order to improve diagnosis and treatment of this condition.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Low back pain (≥ 6 months) with or without pain radiating to the legs or radiating to the neck
Positive medial branch blocks, suggesting that the pain originates from the lumbar facet joints
Average pain intensity of ≥ 3/10 in the 24-hour period before the initial visit
Pain primarily localized in the lower back

Exclusion criteria

Inadequate pain relief or relief of less than three months following selective thermoablation of medial lumbar branches by radiofrequency
Neurological, cardiovascular, or pulmonary disorders
Comorbid pain syndrome
History of surgical intervention in the back
A corticosteroid infiltration within the past year
Pregnancy (current or planned during the course of the study)
Contra-indication to Magnetic Resonance Imaging (MRI)