Brain Reaction to Treatment of Nicotine Dependence

US Department of Veterans Affairs (VA)

Status and phase: Completed; Phase 1

Conditions: Nicotine Dependence

Treatments: Drug: Zyban

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00108173

ADRD-018-02S

Details and patient eligibility

About

The purpose of the study was to determine how the treatments for cigarette craving work.

Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

Full description

PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.

Enrollment: 104 patients

Sex: All

Ages: 21 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Heavy smoker, more than one pack per day
• Free of medical conditions or medications that affect brain activity
• Not pregnant

Exclusion criteria

Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

Trial design

104 participants in 1 patient group

Arm 1

Other group

Treatment:

Drug: Zyban