Brain Stimulation During Arm Immobilisation (ImmobiStim)

Lancaster University

Status: Completed

Conditions: Muscle Loss

Treatments: Other: Transcranial Magnetic Stimulation (TMS)

Study type: Interventional

Funder types: Other

Identifiers

NCT04130581

PSA1775

Details and patient eligibility

About

The research project explores how non-invasive brain stimulation can be used to detect and ameliorate loss of muscle strength after inactivity. At present, there is a limited understanding of how to maintain muscle strength during inactivity. Increasing evidence indicates that reduction in muscle strength following immobilisation is associated with reduced cortical motor output. Therefore, the aim of the study is to test if brain stimulation, can maintain cortical motor output and ameliorate the loss of muscle strength following immobilisation.

Enrollment: 24 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• right-handed
• aged 18-30
• healthy BMI

Exclusion criteria

• no primary muscle disorders
• no open wounds or skin conditions to arms and hands
• no neurological disorders or history of
• no history of fainting/convulsions
• no metal implanted into head/eye/neck
• non-smoker
• no arm, hand, fingers, shoulder injuries

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups

TMS

Experimental group

Description:

Six 30-pulse trains of 20 Hz repetitive Transcranial Magnetic Stimulation to left primary motor cortex hand area, separated by 60 seconds, repeated at 0, 24, 48, and 72 hours post-immobilisation.

Treatment:

Other: Transcranial Magnetic Stimulation (TMS)

Sham

Sham Comparator group

Description:

Six 30-pulse trains of 20 Hz repetitive sham Transcranial Magnetic Stimulation above, but not in contact with, the head, separated by 60 seconds, repeated at 0, 24, 48, and 72 hours post-immobilisation.

Treatment:

Other: Transcranial Magnetic Stimulation (TMS)