Brain Substrates for Cardiovascular Stress Physiology

Baylor University

Status: Enrolling

Conditions: Stress Reaction

Treatments: Other: Low-level laser therapy (LLLT)

Study type: Interventional

Funder types: Other

Identifiers

NCT05298956

1437574

Details and patient eligibility

About

Transcranial infrared laser stimulation is a non-invasive neuromodulation technique. The study will examine the effect of transcranial infrared laser stimulation on cardiovascular and metabolic responses to stress.

Full description

Physiological responses to stress may be a potential pathway by which psychological stress relates to cardiovascular disease. Disproportionate (metabolically exaggerated) stressor-evoked cardiovascular reactions may accelerate atherosclerosis or influence risk of greater cardiovascular disease endpoints. The aim of this project is to use an experimental approach to examine if neuromodulation (transcranial infrared laser stimulation) alters stressor-evoked metabolic and cardiovascular responses.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

18-30 years old

Exclusion criteria

History of a diagnosed chronic medical or neurological disorder Current pregnancy Current illness or infection (e.g., cold, flu) Any condition that would prohibit them from engaging in physical exercise

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Sham

Sham Comparator group

Description:

Participants will receive sham laser to the right forehead.

Treatment:

Other: Low-level laser therapy (LLLT)

Transcranial infrared laser stimulation

Active Comparator group

Description:

Participants will receive transcranial infrared laser stimulation to the right forehead.

Treatment:

Other: Low-level laser therapy (LLLT)