Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura. (MINOTAURE)

Toulouse University Hospital

Status: Completed

Conditions: Migraine With Aura

Treatments: Other: Transcranial Doppler; Other: Magnetic resonance imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT02708797

RC31/15/7815

2015-A01982-47 (Other Identifier)

Details and patient eligibility

About

Migraine with aura (MA) is an independent risk factor for stroke and is associated with silent brain infracts and T2 white matter hyperintensities on MRI. Previous studies using Transcranial Doppler (TCD) have shown an impairment of cerebral autoregulation in MA patients. Studies with positron emission tomography have demonstrated an activation of brain stem areas during migraine attack. An increased density of brain stem grey matter as measured on MRI with voxel based morphometry (VBM) has been found in MA patients. As brain arteries and arterioles are innervated by ascending tracts from aminergic brainstem nuclei, th study hypothesize a negative correlation between the density of brainstem nuclei and the efficiency of cerebral autoregulation in MA patients compared with controls.

Brainstem grey matter density will be studied with a MRI Philips 3 Tesla with a 32-channel antenna and voxel-based morphometry (VBM) cerebral autoregulation will be measured in the time domain using Transcranial Doppler (TCD) and the Mx method.

MA patients will be studied in a headache-free period. MRI and Transcranial Doppler (TCD) are non-invasive technics and will be performed on the same day.

Enrollment: 46 patients

Sex: All

Ages: 30 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Migraine with aura patients : fulfilling the International Classification of Headache Disorders-3 beta criteria of MA
• Control group : Gender- and age-matched subjects without history of migraine with or without aura or any other headache

Exclusion criteria

• History of illness or injury of central or peripherical nervous system
• Previous history of a disease potentially impairing cerebral autoregulation (diabetes, sleep apnea syndrome, uncontrolled hypertension, cardiac arrhythmia, hearth failure, carotid stenosis)
• Contraindications related to MRI
• Absence of temporal acoustic window
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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46 participants in 2 patient groups

Migraine with aura Patients

Other group

Description:

Patients with migraine with aura will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler.

Treatment:

Other: Magnetic resonance imaging

Other: Transcranial Doppler

Controls

Other group

Description:

Control group with healthy volunteers will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler.

Treatment:

Other: Magnetic resonance imaging

Other: Transcranial Doppler