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Breaking Sitting and Metabolic Health in Sedentary Overweight and Obese Adults

N

National Taiwan Normal University

Status

Completed

Conditions

Gut Hormones
Metabolic Health
Energy Balance

Treatments

Behavioral: Prolonged sitting
Behavioral: Breaking sitting

Study type

Interventional

Funder types

Other

Identifiers

NCT05306678
201912HM107-

Details and patient eligibility

About

The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary overweight and obese adults.

Full description

Two trials are included in this project - Prolonged sitting and Breaking sitting.

In the Prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min. In the Breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. Blood samples were collected in a regular pattern throughout the trials. Energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.

Enrollment

13 patients

Sex

All

Ages

20 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Physical inactive males and females
  • Aged between 20 and 45 years
  • Overweight and obese healthy adults (waist circumference greater than 90 cm for males and 80 cm for females)
  • Weight stable for more than 3 months (no change in weight +/- 3%)
  • Non-smoker
  • Able to walk comfortably on a treadmill

Exclusion criteria

  • Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
  • Waist circumference < 90 cm for male and < 80 cm for female
  • Taking medications that may influence lipid or carbohydrate metabolism or immune system function
  • Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

13 participants in 2 patient groups

Prolonged sitting
Experimental group
Description:
Prolonged sitting
Treatment:
Behavioral: Prolonged sitting
Breaking sitting
Experimental group
Description:
Breaking prolonged sitting
Treatment:
Behavioral: Breaking sitting

Trial contacts and locations

1

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Central trial contact

Yung-Chih Chen, PhD

Data sourced from clinicaltrials.gov

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