ClinicalTrials.Veeva

Menu

Breast Cancer After Ovarian Cancer During and/or After Therapy: Genomic Evaluation (Gen-eva)

I

Institute of Hospitalization and Scientific Care (IRCCS)

Status

Enrolling

Conditions

BRCA-Associated Breast Carcinoma

Treatments

Genetic: Next-generation sequencing (NGS) assay TruSight Oncology 500 (TSO 500).

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

This study will investigate, in patients with germline BRCA-1/2 mutations and breast cancer, arising during and / or after treatment with platinum-based chemotherapy and / or with PARP-inhibitors for ovarian cancer, the presence of molecular alterations potentially involved in the mechanisms of resistance to antineoplastic treatment on breast and ovarian tumor tissue.

Enrollment

10 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Written informed consent.
  • Age older than 18 years.
  • Germline BRCA1/2 mutation.
  • Histologically confirmed ovarian cancer treated with platinum-based chemotherapy and/or PARP inhibitors.
  • Histologically confirmed breast cancer occurred during or after therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer.
  • Availability of FFPE breast and ovarian tumor samples.

Exclusion criteria

  • Other malignancies in the last 2 years.
  • Prior chemotherapy or radiation therapy for other malignancies.

Trial design

10 participants in 1 patient group

Patients with germline BRCA1/2 patitents
Description:
Women with germline BRCA-1/2 mutations, previously treated or undergoing treatment with platinum-based chemotherapy and/or PARP inhibitors for ovarian cancer, who have developed breast cancer, subjected to genomic profiling of breast and ovarian tumor samples.
Treatment:
Genetic: Next-generation sequencing (NGS) assay TruSight Oncology 500 (TSO 500).

Trial contacts and locations

1

Loading...

Central trial contact

IDA PARIS, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems