Breast Density Change Predicting Response to Adjuvant Aromatase Inhibitor (DEAR)

Seoul National University

Status: Active, not recruiting

Conditions: Invasive Breast Cancer; Estrogen Receptor Positive Breast Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01765049

SNUHBCC001

Details and patient eligibility

About

Breast density change after short term use of aromatase inhibitor in postmenopausal ER positive breast cancer would predict endocrine responsiveness

Full description

Inclusion criteria ER positive breast cancer Postmenopause women Older than 60yr S/P bilateral salphingo-oophorectomy No menstruation history within 1yr and FSH>30mIU/mL Ipsilateral invasive breast cancer Undergone curative resection No evidence of distant metastasis Capable of breast MRI

Enrollment: 260 patients

Sex: Female

Ages: Under 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ER positive invasive breast cancer Postmenopause women age 60yrs or older s/p bilateral salphingo-oophorectomy No history of menstruation and FSH>30mIU Planned for aromatase inhibitor Unilateral breast cancer Curative resection No evidence of distant metastasis

Exclusion criteria

• Bilateral breast cancer Male breast cancer Acceptable for breast MRI Pregnancy or lactation