Breath Analysis in Asthma

University of Zurich (UZH)

Status: Completed

Conditions: Asthma; Mass Spectrometry; Exhaled Breath

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02450461

KEK-ZH-Nr. 2015-0148

Details and patient eligibility

About

The purpose of this study is to answer the question whether a disease-specific profile of breath in patients with asthma can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Enrollment: 60 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Confirmed asthma. Diagnosis of asthma is made with episodic chest symptoms and a documented reversibility of at least 12% and/or 200 ml in FEV1 after 200 ug of inhaled salbutamol or airway hyperresponsiveness in the case of normal lung function testing (PC20 methacholine < 4mg/ml) at the time of diagnosis.
2. Age between 18 and 80 years at study entry.
3. Healthy controls: never-smokers, normal spirometry (baseline FEV1 > 85% predicted and FEV1/FVC greater than 0.7).

Exclusion criteria

1. Asthma exacerbation within the last 6 weeks, defined as worsening of asthma symptoms requiring a change in therapy by a physician or a change in regular asthma therapy (including short course of oral corticosteroids)
2. Any lung disease other than asthma.
3. Acute inflammatory disease (e.g. common cold) within the last 4 weeks.
4. Regular intake of oral steroids.
5. Active smoking habits / positive history of smoking.
6. Acute or chronic hepatic disease.
7. Renal failure or renal replacement therapy.
8. Pregnancy.

Trial design

60 participants in 2 patient groups

Asthma

Description:

20 patients with asthma

Treatment:

Other: no intervention

Controls

Description:

20 control subjects with no apparent lung disease and normal lung function testing. Matched for gender, age and smoking history.

Treatment:

Other: no intervention