Breath Analysis in Chronic Obstructive Lung Disease (COPD)

University of Zurich (UZH)

Status: Completed

Conditions: COPD

Study type: Observational

Funder types: Other

Identifiers

NCT02186639

KEK-ZH-Nr. 2014-0088

Details and patient eligibility

About

To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Full description

This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC < 0.7) performed within the last 6 months
• age between 18 and 80 years at study entry
• healthy controls: normal spirometry

Exclusion criteria

• COPD exacerbation within the last 6 weeks
• any lung disease other than COPD
• acute inflammatory disease (e.g. common cold) within the last 6 weeks
• acute or chronic hepatic disease
• renal failure or renal replacement therapy

Trial design

40 participants in 2 patient groups

COPD

Description:

40 COPD patients (20 non-frequent and 20 frequent-exacerbators). No intervention.

Controls

Description:

Subjects with no apparent lung disease and normal lung function testing. Matched for age, gender and smoking history (pack years). No intervention.