Breath Analysis in Lung Fibrosis

University of Zurich (UZH)

Status: Completed

Conditions: Idiopathic Lung Fibrosis; Idiopathic Pulmonary Fibrosis

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02437448

KEK-ZH-Nr. 2014-0573

Details and patient eligibility

About

The aim of the study is to answer the question whether a disease specific profile of breath in patients with idiopathic lung fibrosis can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Enrollment: 31 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Clinical symptoms consistent with IPF
2. Age 40 through 80 years
3. Diagnosis of UIP or IPF by HRCT and surgical lung biopsy as outlined in table 1. Only patients fulfilling the category "YES" will be included in the study.
4. Extent of fibrotic changes (honeycombing, reticular changes) greater than extent of emphysema on HRCT scan
5. No features supporting an alternative diagnosis

Exclusion criteria

1. Acute exacerbation within the last 6 weeks.
2. Any relevant lung disease other than pulmonary fibrosis.
3. Acute inflammatory disease (e.g. common cold) within the last 6 weeks.
4. Acute or chronic hepatic disease.
5. Renal failure or renal replacement therapy.

Trial design

31 participants in 2 patient groups

Idiopathic lung fibrosis

Description:

20 IPF patients

Treatment:

Other: No intervention

Controls

Description:

20 subjects with no apparent lung disease and normal lung function testing. Matched for gender, age and smoking history.

Treatment:

Other: No intervention