Breath Volatile Organic Compounds Patterns of Lung Transplant Patients With Chronic Lung Allograft Dysfunction

Prof. Dr. Jens Hohlfeld

Status: Completed

Conditions: Chronic Lung Allograft Dysfunction (CLAD)

Treatments: Other: Collection of exhaled breath volatile organic compounds

Study type: Observational

Funder types: Other

Identifiers

NCT02836938

TXVOC

Details and patient eligibility

About

It's the aim of this study to clarify, whether the non-invasive assessment of breath can serve as a novel clinical tool to assist in the diagnosis of CLAD. If different stages of BOS can be discriminated by the level of certain VOCs than there would also be a potential to actually predict the development at an early stage and would enable an earlier intervention.

Enrollment: 75 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Outpatient bilateral lung transplant recipients including combined transplants

Exclusion criteria

• Active Smoking Oxygen therapy Infection with multi or pan-resistant bacteria

Trial design

75 participants in 3 patient groups

Severe

Description:

Severe chronic lung allograft dysfunction (CLAD), bronchiolitis obliterans syndrome (BOS), stage 3

Treatment:

Other: Collection of exhaled breath volatile organic compounds

Mild

Description:

Mild chronic lung allograft dysfunction (CLAD), bronchiolitis obliterans syndrome (BOS), stage 1-2

Treatment:

Other: Collection of exhaled breath volatile organic compounds

Control

Description:

Bronchiolitis obliterans syndrome (BOS), stage 0

Treatment:

Other: Collection of exhaled breath volatile organic compounds