BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders (B-GLAD)

McGill University

Status: Enrolling

Conditions: Generalized Anxiety Disorder; Oxygenation Sensitive CMR

Treatments: Diagnostic Test: Cardiac MRI

Study type: Observational

Funder types: Other

Identifiers

NCT05574140

2020-6298

Details and patient eligibility

About

This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.

Full description

The investigators will prospectively analyze OS-CMR data from patients with a generalized anxiety disorder from one site. The investigators will observe how an anxiety disorder affects the OS-CMR data. In a follow-up MRI scan, the investigators will look at the OS-CMR of a subgroup who have anxiety disorder and are also undertaking cognitive behavioural therapy to asses how and if this therapy affects the OS-CMR data.

Enrollment: 84 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patient population:

Age 18-55,

• Confirmation of an anxiety disorder as identified by the PSWQ,
• No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system (except anxiety and depression)
• Non-smoker

Healthy Volunteers:

• Age 18-55
• No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system
• Non-smoker

Exclusion criteria

• General MRI contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, pregnancy
• History of significant neurological disease or illness that is not anxiety (e.g. Dementia, stroke)
• Hemodynamically unstable conditions
• Significant or uncontrolled arrhythmias
• Severe pulmonary disease
• Recent (<90 days) myocardial infarction
• Recent (<90 days) surgery or coronary intervention
• Consumption of caffeine (caffeinated beverages, coffee, tea, cocoa, chocolate) within 12h of the exam
• Use of benzodiazepines or other short-acting anxiety medications (<1 day)

Trial design

84 participants in 2 patient groups

Patient Population

Description:

Participants diagnosed with Generalized Anxiety Disorder

Treatment:

Diagnostic Test: Cardiac MRI

Healthy Volunteers

Description:

Participants with no pre-existing conditions and who are on no medications.

Treatment:

Diagnostic Test: Cardiac MRI