Breathing Rescue for SUDEP Prevention (BreatheS)

The University of Texas System (UT)

Status: Enrolling

Conditions: Focal Epilepsy

Treatments: Device: Brain mapping with stimulation; Other: Breathing tasks

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05981755

HSC-MS-20-1228

R01NS133743 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of intractable focal epilepsy
• admitted to the Epilepsy Monitoring Unit (EMU) at Memorial Hermann-Texas Medical Center for intracranial subdural strips, grids, or depth electrode placement study (invasive video-EEG)

Exclusion criteria

• respiratory, cardiac or cerebrovascular disease
• pregnancy
• prisoners

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Breathing tasks and Brain mapping with stimulation

Experimental group

Treatment:

Other: Breathing tasks

Device: Brain mapping with stimulation