BREMISS : Brain Resilience Minor Stroke Study

Regional University Hospital Center (CHRU)

Status

Not yet enrolling

Conditions

Stroke Ischemic

Treatments

Diagnostic Test: Cerebral MRI without contrast agent injection

Genetic: saliva sample

Other: Questionnaires

Study type

Interventional

Funder types

Other

Identifiers

NCT06995040

29BRC23.0188 - BREMISS

Details and patient eligibility

About

All patients eligible recorded in the Brest Stroke Registry (BSR) will be proposed to have either a telephone interview or a face-to-face interview.

In the case of telephone interview, they will be proposed to have a saliva kit for DNA analysis send to their home at the time as the self-questionnaires that will need to be send back to the hospital.

In the case of face-to-face interview, they will be proposed to have on the spot a saliva sample for DNA and a cerebral MRI.

Around 1000 patients can be included.

Full description

The study is a retrospective study for pairing the population-based stroke registry and hospital medical record data and prospective study for calling back patient more than 4 years for new clinical, cognitive, thymic and quality of life evaluations and for DNA sample and cerebral MRI realization Duration of recruitment is anticipated to last between 2 years and 2 years and half.

The principal objective is to develop a predictive model of quality of life more than 4 years after stroke onset in patients with minor stroke based on initial (first days after stroke onset) patients characteristics based on the assumption that more than 4 years after a stroke the related sequelae are going to be stable.

Enrollment

1,000 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Cases of stroke in the Brest Stroke Registry (BSR)
Ability to sign informed consent
Patients followed-up > 4 years during the study period
NIHSS score ≤ 5 on admission
First stroke above 18 and before 75-year old
Rankin before stroke < 1
Possibility to draw saliva samples for genomic study
Possibility to perform Cerebral MRI

Exclusion criteria

Patients with transient neurological deficits resolving within one hour and normal brain imaging will be excluded.
Not affiliated to social security
Patient under legal protection or deprived of liberty by a judicial or administrative decision
Patient unable to sign informed consent
Patient whose follow-up will be impossible