Broccoli Sprouts for Mild Ulcerative Colitis

University of Michigan

Status

Completed

Conditions

Ulcerative Colitis Chronic Mild

Ulcerative Colitis

Treatments

Dietary Supplement: 3 Servings of broccoli sprouts

Dietary Supplement: 1 Serving of broccoli sprouts

Study type

Interventional

Funder types

Other

Identifiers

NCT05507931

HUM00210637

2022-67017-36303 (Other Grant/Funding Number)

Details and patient eligibility

About

The goal of this study is to determine the number of servings of broccoli sprouts sufficient to (1) increase sulforaphane levels in the stool and blood and (2) reduce inflammatory markers in patients with mild ulcerative colitis. This is a pilot feasibility study to prepare for a larger randomized controlled trial.

Enrollment

23 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Documented endoscopic diagnosis of ulcerative colitis
Currently being treated with a stable dose of 5-ASAs, steroids, or any other medication approved for ulcerative colitis
- If on 5-ASA, no dose changes within 2 weeks before the Day 0 visit
- If on steroids, prednisone dose not more than 20 mg daily and entocort not more than 9 mg daily, with no dose changes within 2 weeks before the Day 0 visit
- All other medications require a stable dose for at least 8 weeks prior to enrollment.
- No dose changes to any IBD medication anticipated for the duration of the study
Body Mass Index (BMI) values 18.5-40 kg/m2
Not on total parenteral nutrition (TPN) or receiving tube feeds.
Ability to understand the study procedures, benefits and risks, and sign a written informed consent document.
Able to fill out questionnaires regarding dietary intakes, bowel symptoms, and study experience

Exclusion criteria

Taking Non-steroidal anti-inflammatory drugs (NSAIDs)
Following a medically-prescribed diet, on Total parenteral nutrition (TPN), or tube feeds
Newly diagnosed (within past month), or uncontrolled diabetes or cardiovascular disease
Antibiotics in the previous 2 weeks
Consumption of more than 5 ½ cups of servings/day of fruits and vegetables as assessed by the National Cancer Institute (NCI) Diet History Questionaire III online Food Questionnaire.
A known allergy or sensitivity to cruciferous vegetables like arugula, bok choy, broccoli, cabbage, cauliflower, or collard greens