Bromelain for Post-surgery Facial Swelling

Mohamed Bazina

Status: Enrolling

Conditions: Malocclusion

Treatments: Dietary Supplement: Bromelain

Study type: Interventional

Funder types: Other

Identifiers

NCT07115212

99500

Details and patient eligibility

About

The goal of this clinical trial is to learn if Bromelain Supplement works to decrease the amount of swelling or the amount of time swelling is present following jaw surgery. It will also learn about the safety of Bromelain supplement. The main questions it aims to answer are:

Does Bromelain decrease facial swelling following orthognathic, or jaw, surgery? Does Bromelain supplement decrease the amount of time that patients are swollen following orthognathic, or jaw, surgery?

Participants will:

Take Bromelain supplement once daily for 9 days total. Take 2 days before surgery and 7 days following surgery.

Keep a log of when the bromelain supplement is taken as well as another other medications.

Visit the clinic with pre and post surgical protocol

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• undergoing orthognathic surgery

Exclusion criteria

• craniofacial anomalies
• incomplete patient data
• systemic disease that could affect healing
• allergy to latex or pineapple
• under 18 years of age
• non english speaking

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Bromelain Supplement

Experimental group

Description:

1000mg bromelain supplement once a day, 2 days prior to and 7 days following surgery

Treatment:

Dietary Supplement: Bromelain

Control

No Intervention group

Description:

Standard of care