Bronchial Colonization With Fungi and Late Respiratory Acquired Pneumonia (CBF et PAVMt)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Ventilator Acquired Pneumonia

Treatments: Procedure: biological sampling; Procedure: endotracheal aspiration; Procedure: sampling blood

Study type: Interventional

Funder types: Other

Identifiers

NCT01770015

2011-A00767-34

Details and patient eligibility

About

Ventilator acquired pneumonia (VAP) are severe nosocomial infections. On the other side, bronchial fungi colonization is commonly observed in ICU; therefore, the investigators propose to study the role of bronchial fungi colonization on the occurrence of VAP taking into account the immune status of the patient and the antibiotic and antifungal treatments he has received.

Enrollment: 213 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient ventilated for at least 5 days

Exclusion criteria

• invasive infection Candida sp defined by : candidemia, isolation of Candida from a normally sterile site, candida pneumoniae.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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213 participants in 1 patient group

ventilated patient

Experimental group

Description:

all patients underwent the same diagnostic test . cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization. HLA DR antigen, cytokines (IL 6 and 10), B-glucan. fungi and bacteria endotracheal aspiration

Treatment:

Procedure: biological sampling

Procedure: endotracheal aspiration

Procedure: sampling blood