Bronchial Hyperreactivity During Histamine Passive Exposure

Centre Hospitalier Universitaire Saint Pierre

Status: Completed

Conditions: Asthma; Bronchial Hyperresponsiveness

Treatments: Drug: histamine-benzylic alcohol (magistral preparation)

Study type: Interventional

Funder types: Other

Identifiers

NCT01937494

AK/13-03-34/4235

Details and patient eligibility

About

Bronchial hyperresponsiveness consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma (metacholine or histamine).Protection are used to avoid passive exposure of the technicians performing the test, despite the absence of evidence that they could develop a bronchoconstriction even if they suffer from BHR.The purpose of the study is to determine if patients with a high level of bronchial hyperreactivity and exposed passively to histamine during a bronchial challenge, are developing a bronchoconstriction, when placed in the same conditions that the technicians performing these tests.

Full description

Bronchial hyperresponsiveness (BHR) consists in excessive response to bronchial stimuli.Bronchial challenge test is used to confirm/exclude asthma.BHR is also present in other diseases such as allergic rhinitis, Chronic Obstructive pulmonary disease,heart failure..

Thes test is performed with metacholine or histamine with spirometric documented response to incremental doses.Protection are used to avoid passive exposure of the technicians performing the test, despite the absence of evidence that they could develop a bronchoconstriction if they suffer from BHR.

The purpose of the study is to determine if patients, newly diagnosed with a high level of bronchial hyperreactivity and exposed passively to histamine during a bronchial challenge, are reacting to histamine when placed in the same conditions that the technicians performing these tests.

Enrollment: 13 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients with positive histamine challenge test (first dose)

Exclusion criteria

• other active respiratory disease

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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13 participants in 1 patient group

asthma patients

Experimental group

Description:

patients who show a positive response at the first dos of histamine challenge test will be enrolled

Treatment:

Drug: histamine-benzylic alcohol (magistral preparation)