Bronchial Hyperreactivity in Children With Crohn Disease

Rambam Health Care Campus

Status: Completed

Conditions: Crohn's Disease

Treatments: Other: Blood Test; Other: PCDAI; Other: Fractional Exhaled NO (FENO); Other: Methacholine Challenge Test

Study type: Observational

Funder types: Other

Identifiers

NCT01297907

Crohn's

Details and patient eligibility

About

Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to determine the frequency of bronchial hyperreactivity in pediatric patients followed and treated for Crohn disease.

Methods: Twenty-three children with Crohn disease completed a questionnaire, followed by spirometry, Methacholine Challenge Test (MCT) and determination of Fractional Exhaled NO (FENO). The control group included patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT).

Enrollment: 47 patients

Sex: All

Ages: 6 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children with Crohn disease
• Children that can perform lung function tests (MCT)

Exclusion criteria

• Upper respiratory tract infection last month
• Fever or Pneumonia last month
• Smoking
• Other chronic diseases
• Other respiratory diseases

Trial design

47 participants in 2 patient groups

Crohn's Patients

Description:

Random Crohn's Disease Patients that can perform Methacholine Challenge Test (MCT)

Treatment:

Other: Blood Test

Other: PCDAI

Other: Fractional Exhaled NO (FENO)

Other: Methacholine Challenge Test

Negative MCT

Description:

Patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT)

Treatment:

Other: Fractional Exhaled NO (FENO)

Other: Methacholine Challenge Test