Bronchoalveolar Immune Response Determination (BIRD)

Bossink, A.W.J.

Status: Completed

Conditions: Extrinsic Allergic Alveolitis

Study type: Observational

Identifiers

NCT01237145

BIRD01

Details and patient eligibility

About

The purpose of this study is to establish if cells present in lung tissue during extrinsic allergic alveolitis (EAA) are able to elicit an immune response against specific antigens. The hypothesis is: cells in BAL lavage fluid from patients with EAA will be responsive to specific antigens and this response can be measured using ELISPOT.

Full description

Subjects suffering from extrinsic allergic alveolitis caused by pigeons will undergo a broncho alveolar lavage. Cells obtained from this BAL will be used for ELISPOT technique with pigeon specific antigens

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• suspicion of pigeon induced extrinsic alveolitis

Exclusion criteria

• use of oral steroids
• unable to give informed consent
• age below 18

Trial design

10 participants in 2 patient groups

non-EAA, pigeon

Description:

subject with BAL because of diseases not suspected to be EAA

EAA, pigeon

Description:

Bird fanciers with a typical clinical presentation suspected for pigeon induced EAA