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Bronchoreversibility and Radiologic Morphology of Emphysema

U

University of Rome Tor Vergata

Status

Unknown

Conditions

Emphysema
COPD

Treatments

Drug: Bronchodilators

Study type

Observational

Funder types

Other

Identifiers

NCT02008162
BREPTV-108.7

Details and patient eligibility

About

To assess response to bronchodilation with tiotropium plus salbutamol in patients with severe emphysema and analyze relationships between bronchoreversibility response and semiquantitative computed-tomography based emphysema severity measures.

Enrollment

60 estimated patients

Sex

All

Ages

20 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • Radiologic evidence of severe heterogeneous emphysema
  • GOLD COPD class III-IV
  • No other significant pulmonary comorbidity
  • Quit smoking since at least 4 months

Trial design

60 participants in 1 patient group

Bronchodilators
Description:
Patients with severe heterogeneous emphysema selected as potential candidtes for lung volume reduction surgery. Bronchodilators employed for the study include albuterol 200µg and tiotropium bromide 18 µg administered by puffs following a first spirometry and plethysmography performed after a washout period of 48h from all bronchodilators and subsequently repeated within 30 min after bronchodilators administration.
Treatment:
Drug: Bronchodilators

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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