Bronchoreversibility and Radiologic Morphology of Emphysema

University of Rome Tor Vergata

Status: Unknown

Conditions: Emphysema; COPD

Treatments: Drug: Bronchodilators

Study type: Observational

Funder types: Other

Identifiers

NCT02008162

BREPTV-108.7

Details and patient eligibility

About

To assess response to bronchodilation with tiotropium plus salbutamol in patients with severe emphysema and analyze relationships between bronchoreversibility response and semiquantitative computed-tomography based emphysema severity measures.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Radiologic evidence of severe heterogeneous emphysema
• GOLD COPD class III-IV
• No other significant pulmonary comorbidity
• Quit smoking since at least 4 months

Trial design

60 participants in 1 patient group

Bronchodilators

Description:

Patients with severe heterogeneous emphysema selected as potential candidtes for lung volume reduction surgery. Bronchodilators employed for the study include albuterol 200µg and tiotropium bromide 18 µg administered by puffs following a first spirometry and plethysmography performed after a washout period of 48h from all bronchodilators and subsequently repeated within 30 min after bronchodilators administration.

Treatment:

Drug: Bronchodilators